Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
نویسندگان
چکیده
منابع مشابه
A novel in vivo model of puncture-induced iris neovascularization
PURPOSE To assess iris neovascularization by uveal puncture of the mouse eye and determine the role of angiogenic factors during iris neovascularization. METHODS Uveal punctures were performed on BalbC mouse eyes to induce iris angiogenesis. VEGF-blockage was used as an anti-angiogenic treatment, while normoxia- and hypoxia-conditioned media from retinal pigment epithelium (RPE) cells was use...
متن کاملExperimental immunogenic rubeosis iridis.
We have developed a primate model of rubeosis iridis in monkeys systemically sensitized to crystalline beef insulin. After intravitreal insulin injection, the dose-related immunogenic inflammation includes cells, flare, fibrin, and blood in the anterior chamber. With more severe inflammation, posterior synechiae, iris bombé, and cataracts occur. Of particular importance, new blood vessels deve...
متن کاملEffect of squalamine on iris neovascularization in monkeys.
PURPOSE To investigate the effect of squalamine, an antiangiogenic aminosterol, in an experimental model of iris neovascularization. METHODS Iris neovascularization was created in cynomolgus monkeys by occluding retinal veins with an argon laser and inducing persistent hypotony with a central corneal suture. Twenty-four eyes were treated in three groups. In Group 1, four eyes were injected in...
متن کاملDevelopment and classification of rubeosis iridis in diabetic eye disease.
The evolution and characteristics of diabetic rubeosis were studied in 33 eyes, and the following vascular abnormalities were found: (1) Dilated leaking capillaries around the pupil; (2) irregular or slow filling of the radial arteries; (3) superficial arborising newly formed vessels, usually starting in the chamber angle; and (4) dilatation and leakage of the radial vessels either before or af...
متن کاملNeovascularization of the iris: an experimental model in cats.
Neovascularization of the iris was induced in cats by removing the vitreous and lens and creating a rhegmatogenous retinal detachment. The presence of new blood vessels on the anterior surface of the iris was verified from the second month onward by slit lamp examination, as well as by light microscopy six to twelve months after the operation. Control eyes undergoing vitrectomy and lensectomy, ...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2018
ISSN: 1940-087X
DOI: 10.3791/57398